Brain Pathology

Clinical History (pre access to CT and MRI imaging) This 51-year old woman had surgery for breast carcinoma 2 years before presentation. Her main complaint was left-sided ataxia for the 2 weeks prior, and this had been preceded by a fainting attack...

Clinical History In the 1970s, a 31-year-old woman presented with severe headache and diplopia on a background of having a pigmented skin lesion (diagnosed as an invasive skin melanoma) removed from her neck 8 months earlier. Clinical examination...

Clinical History A 62-year-old woman presented with disorientation to time, place and person. Physical examination revealed no localized neurological signs. Radiological investigations revealed a space occupying lesion in the floor of the 3rd ventricle...

Clinical History A 56-year old male presented with a generalized seizure. He remained unconscious after this seizure and later died. A collateral history revealed 6 months of progressive confusion, short-term memory loss and personality change...

Clinical History Over a 3-year period, a 57-year-old woman had intermittent frontal headache and memory disturbance with progression to psychiatric disturbance, and ultimately vomiting and meningeal signs. Localizing neurological signs only developed...

Clinical History A 73-year-old female was admitted with new left-sided hemiplegia. On further questioning she revealed a 3-month history of headaches, nausea and deteriorating balance. CT brain revealed an inoperable brain tumor. She died 1 week after...

Clinical History Five days before admission this 38-year old female experienced the sudden onset of pain behind the right eye, associated with a slow development of weakness of the left leg. Examination disclosed left-hemiparesis in a confused...

Clinical History The patient was an 80-year old man who suddenly lost consciousness. On examination there was a right gaze palsy, a left hemiplegia and right hemiparesis. Pathology The specimens are coronal sections of the brain at the level of the...

Clinical History A 56-year-old woman with 6 months of intermittent headache and vomiting was admitted to hospital comatose after a grand mal seizure, and failed to regain consciousness. Pathology The specimen is a coronal section of a brain. It is...

Clinical History This patient died at the age of 58 years from post-operative complications following transurethral resection of the prostate. At the ages of 28 and 35, he had suffered two episodes of transient neurological deficit. However, at 50 years,...

Clinical History A 22-year-old male presented with a 2-week history of generalized malaise, weight loss and bruised skin without any trauma. He recently developed 5 days of productive cough and fevers. He was admitted to hospital for further...

Clinical History A 50-year-old alcoholic was admitted with a 2-week history of weakness and shortness of breath. At the onset of the illness he reported a productive cough, chest pain and blood-stained sputum. Examination revealed a febrile, cyanosed,...

Clinical History A 56-year old male underwent a total gastrectomy and splenectomy for gastric adenocarcinoma. Over a period of two months he developed a progressively unsteady gait, increasing weakness of his left hand and frontal headaches associated...

Clinical History A 29-year old male presented with a 22 month history of headaches and blurred vision. Examination revealed a bi-temporal hemianopia and a left VI nerve palsy. Skull X-ray showed erosion of most of the sphenoid body with some dorsum...

Clinical History The patient was a 51-year old woman who had a cerebrovascular accident resulting in a left hemiplegia 2 years prior to death. At necropsy, she had severe generalized atherosclerosis and an old left ventricular myocardial infarct with an...

Clinical History A 68-year-old female presented with recent onset of seizures and was diagnosed with epilepsy. Collateral history revealed a gradual change in the patient's personality. She subsequently died several months later from a myocardial...

Clinical History The patient was a female aged 24 years, who presented 18 months before death with an abnormal electroencephalogram (EEG) after a single epileptic fit. Six months later she complained of blurred vision and headaches. Bilateral...

Clinical History A woman of 56-years was admitted following 2 episodes of severe headache with loss of consciousness. Clinical examination revealed systemic hypertension with cardiac enlargement, and a right hemiparesis. Angiography showed bilateral...

Clinical History A 37-year-old patient presented to hospital after falling and striking his head, with subsequent symptoms of headache, vomiting and disorientation. CT scan showed dilatation of the lateral ventricles associated with a large mass...